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The phenomenon of digital blanching and cyanosis on exposure to cold was first described properly by Maurice Raynaud in 1862 in his "De l'asphyxie locale et de la gangrene symmétrique des extrémités." Critics complained, however, that his description was based on uncharacteristic patients. Such carping seems inappropriate; if absolute priority is being sought for the description, then it probably belongs to the author of Exodus XII who tells us how Moses "was commanded by the Lord to put his hand into his bosom, and when he withdrew it it was as white as snow." Since Raynaud's time, no one (with
Raynaud's Phenomenon. Ann Intern Med. ;113:563–564. doi: 10.7326/0003-4819-113-7-563_7
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Published: Ann Intern Med. 1990;113(7):563-564.
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