P. H. Chandrasekar, MD
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To the Editors: I wish to point out a significant omission in the otherwise excellent article by Berkman and colleagues (1) on clinical uses of intravenous immunoglobulins. The possible utility of immunoglobulins as adjunctive agents in the management of gram-negative bacterial infection deserves discussion. The high mortality associated with serious gram-negative bacterial infection has generated much interest in the evaluation of antibody efficacy in the treatment of such infections. In 1982, Ziegler and colleagues (2) established that administration of immune serum obtained from volunteers who had been immunized with rough mutants of J5 Escherichia coli decreased the mortality rate by
Chandrasekar PH. Intravenous Immunoglobulins in Gram-Negative Bacteremia. Ann Intern Med. ;113:897–898. doi: 10.7326/0003-4819-113-11-897
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Published: Ann Intern Med. 1990;113(11):897-898.
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