Bryan K. Demarie, MD; George L. Bakris, MD
Studies in various animal models of renal dysfunction show that urinary protein excretion is partly determined by glomerular capillary pressure (1-5). Further, clinical studies have shown that nifedipine, an agent that does not alter glomerular capillary pressure, increases urinary protein excretion and leads to renal dysfunction (6-8). In addition, diltiazem, an agent that lowers glomerular capillary pressure, decreases urinary protein excretion in a manner similar to that of angiotensin-converting enzyme inhibitors in diabetic patients with renal insufficiency and hypertension (9). We conducted a prospective crossover trial to evaluate the effects of diltiazem and nifedipine on urinary protein excretion in diabetic,
Demarie BK, Bakris GL. Effects of Different Calcium Antagonists on Proteinuria Associated with Diabetes Mellitus. Ann Intern Med. ;113:987–988. doi: 10.7326/0003-4819-113-12-987
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Published: Ann Intern Med. 1990;113(12):987-988.
Cardiology, Coronary Risk Factors, Diabetes, Endocrine and Metabolism, Hypertension.
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