Nelson J. Chao, MD; Steven R. Duncan, MD; Gwynn D. Long, MD; Sandra J. Horning, MD; Karl G. Blume, MD
Robbins and colleagues (1) recently reported a syndrome of diffuse alveolar hemorrhage seen in patients after autologous bone marrow transplantation. This entity was noted in 29 of 141 patients (21%) and was associated with an 80% mortality rate (23 of the 29 patients died). Risk factors associated with the development of this syndrome included age over 40 years, underlying solid tumors, high fevers, severe mucositis, leukocyte recovery, and renal insufficiency. The Memorial Sloan-Kettering group (2) also recently reported their experience with pulmonary complications after autologous bone marrow transplantation. Pulmonary hemorrhage was seen 11 of 31 patients (35%) receiving transplants for
Chao NJ, Duncan SR, Long GD, Horning SJ, Blume KG. Corticosteroid Therapy for Diffuse Alveolar Hemorrhage in Autologous Bone Marrow Transplant Recipients. Ann Intern Med. ;114:145–146. doi: 10.7326/0003-4819-114-2-145
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Published: Ann Intern Med. 1991;114(2):145-146.
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