David L. Hahn, MD
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To the Editors: The article by Bufill (1) is a valuable contribution to the discussion of heredity and environment as etiologic factors in colorectal cancer. Most epidemiologic studies have focused on environmental contributions to causation; a recent worldwide observational study, however, has shown racial differences in the incidence of proximal and distal colorectal cancer (2), which could be explained by genetic drift as racial differentiation occurred (3). Racial differences in the incidence of proximal and distal colorectal cancer are further evidence of a probable genetic contribution. It must be emphasized, however, that the differences between proximal and distal colorectal cancer
Hahn DL. Colorectal Cancer: Heredity and Environment. Ann Intern Med. 1991;114:431–432. doi: 10.7326/0003-4819-114-5-431_4
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Published: Ann Intern Med. 1991;114(5):431-432.
Colorectal Cancer, Gastroenterology/Hepatology, Gastrointestinal Cancer, Hematology/Oncology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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