Robert G. Berger, MD; Susan J. Knox, MD, PhD; Ronald Levy, MD; Jeffrey L. Sklar, MD, PhD; Philip Cohen, MD; Thomas Reichert, MD, PhD
We report the case of a patient with mycosis fungoides who developed a progressive arthropathy from malignant synovial infiltration. The arthropathy responded to treatment with a chimeric, human-murine monoclonal antibody against T-helper cells.
At 39 years of age, this previously healthy woman developed a rash over her abdomen and, subsequently, over her thighs and arms. The rash was characterized by hyperkeratotic, erythematous plaques. Two years later, she developed a symmetric, nonerosive small hand-joint arthritis. Tests for rheumatoid factor and antinuclear antibody had negative results.
Over the next year, the patient's rheumatic and cutaneous symptoms responded to neither hydroxychloroquine
Berger RG, Knox SJ, Levy R, Sklar JL, Cohen P, Reichert T. Mycosis Fungoides Arthropathy. Ann Intern Med. 1991;114:571–572. doi: 10.7326/0003-4819-114-7-571
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Published: Ann Intern Med. 1991;114(7):571-572.
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