Edward H. Wagner, MD, MPH
The evidence of an association between nonsteroidal anti-inflammatory drugs (NSAIDs) and renal disease has acquired an all-too-familiar and frustrating pattern—a plausible biologic mechanism and many small reports showing acute toxicity. Yet, no large-scale clinical trials or epidemiologic studies have confirmed the risk in the population. Murray and Brater (1), in a recent editorial, suggested that "well-executed epidemiologic studies using richer clinical databases will not only cause convergence with the findings from interventional studies (and case reports) but will also provide quantitative information on putative risk factors for NSAID-associated renal effects." In this issue of Annals, the study by Sandler and
Wagner EH. Nonsteroidal Anti-Inflammatory Drugs and Renal Disease—Still Unsettled. Ann Intern Med. ;115:227–228. doi: 10.7326/0003-4819-115-3-227
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Published: Ann Intern Med. 1991;115(3):227-228.
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