Reiner Ullrich, MB; Ernst-Otto Riecken, MD; Martin Zeitz, MD; Klinikum Steglitz
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To the Editors: Greenson and colleagues (1) recently defined "acquired immunodeficiency syndrome (AIDS) enteropathy" as "chronic, well-established diarrhea (> 1 month duration) for which no infectious cause can be determined after complete evaluation" but failed to find any mucosal abnormalities characteristic of such enteropathy. We find this definition inadequate for the following reasons: Intestinal dysfunction is found even at early stages of infection with the human immunodeficiency virus (HIV) and in patients without diarrhea or weight loss (2). Further, the detection of an infectious agent does not prove its causative role (3). We have recently found large proportions of both
Ullrich R, Riecken E, Zeitz M, et al. AIDS Enteropathy. Ann Intern Med. 1991;115:328. doi: https://doi.org/10.7326/0003-4819-115-4-328_1
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Published: Ann Intern Med. 1991;115(4):328.
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