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The opening chapter discusses the pharmacokinetic considerations relevant to adjusting doses in the face of impaired renal or hepatic function, dialysis and hemofiltration effects, drug effects on laboratory tests, and metabolic loads related to drug use. The next ten chapters examine in detail considerations in adjustments in drug therapy with the major groups of drugs. The last three chapters review drug-induced liver and kidney disease and electrolyte disorders. The lengthy appended table provides data on percent oral availability, percent protein binding, volume of distribution, metabolism and elimination, normal half-time, anephric half-time, hepatic-disease half-time, dose changes at three levels of renal
Handbook of Drug Therapy in Liver and Kidney Disease. Ann Intern Med. 1991;115:413. doi: 10.7326/0003-4819-115-5-413_3
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Published: Ann Intern Med. 1991;115(5):413.
Gastroenterology/Hepatology, Liver Disease, Nephrology.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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