Christine C. Sanders, PhD
Until the 1980s, infections caused by species of Enterobacter were relatively uncommon. According to the most recent National Nosocomial Infections Surveillance System data (1), however, Enterobacter has replaced Klebsiella pneumoniae as the third leading cause of gram-negative nosocomial infections behind Escherichia coli and Pseudomonas aeruginosa. In fact, it is the third leading cause of all nosocomial pneumonias. The increased prevalence of Enterobacter has paralleled the introduction and increased use of the expanded-spectrum cephalosporins, both in therapy and in prevention of infections in hospitalized patients.
The association between use of newer cephalosporins and infections caused by Enterobacter spp. is made clear
Sanders CC. New β-Lactams: New Problems for the Internist. Ann Intern Med. 1991;115:650–651. doi: 10.7326/0003-4819-115-8-650
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Published: Ann Intern Med. 1991;115(8):650-651.
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