William N. Katkov, MD; Lawrence S. Friedman, MD; Heather Cody, BS; Alison Evans, ScD; George Kuo, PhD; Qui-Lim Choo, PhD; Michael Houghton, PhD; Jules L. Dienstag, MD
Before serologic tests for hepatitis C virus (HCV) were developed (1), elevated serum alanine aminotransferase (ALT) levels and antibody to hepatitis B core antigen were introduced as "surrogate" markers to screen donor blood likely to transmit non-A, non-B hepatitis (2-5). In 1983, anticipating the introduction of donor-blood ALT screening, we studied 100 consecutive blood donors with elevated ALT levels (6). In our report describing this analysis (6), we identified potential causes for the ALT elevation in most of these blood donors; however, no apparent cause for the ALT elevations could be found in 22% of donors. Tests for HCV infection
Katkov WN, Friedman LS, Cody H, Evans A, Kuo G, Choo Q, et al. Elevated Serum Alanine Aminotransferase Levels in Blood Donors: The Contribution of Hepatitis C Virus. Ann Intern Med. ;115:882–884. doi: 10.7326/0003-4819-115-11-882
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Published: Ann Intern Med. 1991;115(11):882-884.
Gastroenterology/Hepatology, Infectious Disease, Viral Hepatitis.
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