Ronald L. Koretz, MD
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To the Editors: Agrawal and coworkers (1) described a prospective, randomized controlled trial comparing sucralfate and misoprostol in the treatment of patients with nonulcer pain associated with the use of nonsteroidal anti-inflammatory drugs (NSAIDs). They observed that patients treated with misoprostol had a five- to ten-fold decrease in the incidence of subsequent gastric ulceration. The implication is that misoprostol is the preferred agent.
The development of a gastric ulcer was the primary end point of the study. The occurrence of any serious complications (for example, hemorrhage or perforation) of ulcer disease was not reported. Other observations indicated a greater percentage
Koretz RL. Prevention of NSAID-induced Gastric Ulcer. Ann Intern Med. ;115:911–913. doi: 10.7326/0003-4819-115-11-911
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Published: Ann Intern Med. 1991;115(11):911-913.
Gastroenterology/Hepatology, Peptic Disease, Peptic Ulcer.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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