Thomas Papo, MD; Patrick Marcellin, MD; Jacques Bernuau, MD; François Durand, MD; Thierry Poynard, MD; Jean-Pierre Benhamou, MD
Alpha-interferon is known to reduce viral replication, to normalize aminotransferase levels, and to reduce hepatic lesions in 40% of patients with chronic hepatitis caused by hepatitis C virus (HCV) infection (1). Alpha-interferon is also known to induce exacerbation of various autoimmune disorders (2). We describe three patients with type-1 autoimmune chronic hepatitis, erroneously diagnosed as chronic hepatitis C, in whom alpha-interferon administration resulted in aggravation of liver disease.
A 20-year-old man complained of nausea and fatigue in February 1988. The alanine aminotransferase (ALT) level was 26.6 μkat/L (normal, 0 to 0.58 μkat/L). The bilirubin level was
Papo T, Marcellin P, Bernuau J, Durand F, Poynard T, Benhamou J. Autoimmune Chronic Hepatitis Exacerbated by Alpha-Interferon. Ann Intern Med. ;116:51–53. doi: 10.7326/0003-4819-116-1-51
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Published: Ann Intern Med. 1992;116(1):51-53.
Gastroenterology/Hepatology, Liver Disease.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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