Kenneth S. Weiss, MD
This content is PDF only. Please click on the PDF icon to access.
To the Editors: Nephrotic range proteinuria is a well-documented side effect of recombinant gamma interferon and all other interferons (1-3). The doses reported to cause this effect have been in the range of 0.25 mg/m2 to 1 mg/m2 body surface area (activity, 1 x 107 units per milligram of protein). I report a case of nephrotic-range proteinuria in a patient receiving therapy at a much lower dose.
A 64-year-old man had wide excision and skin grafting for a Clark level-IV (11.2 mm-thick) malignant melanoma on his midback. He soon thereafter developed axillary adenopathy, consistent with metastatic melanoma. He agreed to
Weiss KS. Nephrotic Range of Proteinuria and Interferon Therapy. Ann Intern Med. 1992;116:347. doi: https://doi.org/10.7326/0003-4819-116-4-347_1
Download citation file:
Published: Ann Intern Med. 1992;116(4):347.
Copyright © 2020 American College of Physicians. All Rights Reserved.
Print ISSN: 0003-4819 | Online ISSN: 1539-3704
Conditions of Use