Robert H. Collins Jr., MD; Barry Cooper, MD; Afzal Nikaein, PhD; Goran Klintmalm, MD, PhD; Joseph W. Fay, MD
The classic requirements for graft-versus-host disease (GVHD) (1) exist in recipients of liver allografts: 1) The donor liver and recipient are histo-incompatible; 2) lymphocytes within the lymph nodes and lymphatics of the donor graft are capable of recognizing the recipient as foreign and reacting to the recipient (for example, hemolysis of ABO-incompatible erythrocytes by allograft-derived antibodies has been well described ); and 3) the recipient is receiving post-transplant immunosuppressive therapy that could conceivably prevent recipient immune cells from eliminating anti-recipient donor cells.
Despite the presence of immunosuppression, GVHD is believed to be a rare phenomenon in liver transplant patients; few
Collins RH, Cooper B, Nikaein A, Klintmalm G, Fay JW. Graft-versus-Host Disease in a Liver Transplant Recipient. Ann Intern Med. ;116:391–392. doi: 10.7326/0003-4819-116-5-391
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Published: Ann Intern Med. 1992;116(5):391-392.
Gastroenterology/Hepatology, Liver Disease, Liver Transplantation.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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