Antonio Aceti, MD; Gloria Taliani, MD
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To the Editors: Esteban and colleagues (1) reported that in Spain a large proportion (about 70%) of blood donors who are found to be reactive for antibodies to hepatitis C virus (HCV) by enzyme-linked immunosorbent assay (ELISA) are confirmed to be positive by a second-generation recombinant immunoblot assay (RIBA-2).
We recently evaluated the ELISA's specificity in normal donors living in tropical communities. For this purpose, sera specimens from 90 African donors (33 from Mogadishu, Somalia; 25 from Mbalmayo, Cameroon; and 22 from Mbabane, Swaziland) that were found by ELISA (Ortho HCV ELISA Test System 2nd Generation, Raritan, New Jersey) to
Aceti A, Taliani G. Hepatitis C Virus Testing in African Sera. Ann Intern Med. 1992;116:427. doi: https://doi.org/10.7326/0003-4819-116-5-427_2
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Published: Ann Intern Med. 1992;116(5):427.
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