Susana A. Ebner, MD; Marie-Claude Badonnel, PhD; Lawrence K. Altman, MD; Lewis E. Braverman, MD
Hyperthyroid Graves disease is an autoimmune disorder characterized by thyrotoxicosis, diffuse goiter, and antibodies directed against the thyrotropin (TSH) receptor, thyroglobulin (Tg), and thyroid peroxidase (TPO). The TSH receptor antibody is believed to stimulate the generation of cAMP in the thyroid, resulting in the increased synthesis and release of the thyroid hormones. The abnormal function of the immune system found in patients with this disease is strongly linked to a genetic predisposition. The incidence of thyroid disease among monozygotic twins is approximately 50%. This lack of complete concordance suggests that environmental factors, including infectious agents such as Yersinia enterocolitica (1)
Ebner SA, Badonnel M, Altman LK, Braverman LE. Conjugal Graves Disease. Ann Intern Med. ;116:479–481. doi: 10.7326/0003-4819-116-6-479
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Published: Ann Intern Med. 1992;116(6):479-481.
Endocrine and Metabolism, Thyroid Disorders.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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