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Letters |15 June 1993

Postoperative Hyponatremia in Menstruant Women

J. Carlos Ayus, MD; Allen I. Areiff, MD

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IN RESPONSE:
Dr. Taylor requests therapeutic details of our patients with hyponatremic encephalopathy [1]. Among 16 treated male patients, the change in serum sodium was 19 mmol after 24 hours and 21 mmol after 48 hours. All seven surviving women were treated with hypertonic NaCl within 1 hour of the diagnosis: Changes in serum sodium were 15 mmol after 24 hours and 18 mmol after 48 hours. Only 7 of the 33 women were treated for their hyponatremia, and therapy was delayed for 5 hours. The serum sodium was then increased by 13 mmol after 24 hours. The only male patient who died had absorbed hypotonic fluid through the bladder. None of the 65 patients had central pontine myelinolysis, and it is now clear that this disorder is not a consequence of the therapy for hyponatremia [2].
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Ayus JC, Areiff AI. Postoperative Hyponatremia in Menstruant Women. Ann Intern Med. 1993;118:984–985. doi: 10.7326/0003-4819-118-12-199306150-00017

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Published: Ann Intern Med. 1993;118(12):984-985.

DOI: 10.7326/0003-4819-118-12-199306150-00017

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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