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Letters |1 November 1993

Histamine-2-Receptor Antagonists and Serum Ethanol Levels

A. W. Jones, MD

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TO THE EDITOR:
I agree with the conclusions of Raufman and colleagues [1] that drugs such as cimetidine and ranitidine that are used to suppress the production of gastric acid do not influence the serum ethanol concentrations reached after moderate alcohol consumption. This is true when alcohol is consumed on an empty stomach as well as after a meal [2]. Accordingly, this drug-alcohol interaction, the subject of unprecedented news media attention, lacks any clinical or medicolegal relevance [3].
However, their inclusion of breath alcohol measurements raised concerns about their analysis. As shown in Table 1, peak serum...
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Jones AW. Histamine-2-Receptor Antagonists and Serum Ethanol Levels. Ann Intern Med. 1993;119:952–953. doi: 10.7326/0003-4819-119-9-199311010-00020

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Published: Ann Intern Med. 1993;119(9):952-953.

DOI: 10.7326/0003-4819-119-9-199311010-00020

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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