Edward E. Telzak, MD; Mary Ann Chiasson, DrPH; Pamela J. Bevier, MPH; Rand L. Stoneburner, MD; Kenneth G. Castro, MD; Harold W. Jaffe, MD
To determine the relative risk for human immunodeficiency virus (HIV-1) seroconversion in patients with and without genital ulcers caused by chancroid, syphilis, and herpes.
A prospective cohort study.
An inner-city, sexually transmitted disease clinic.
Patients seronegative for HIV-1 with and without genital ulcers who were followed for a minimum of 3 months.
Questionnaire to obtain data on demographics, sexual behavior, and illicit drug use; testing for HIV-1 at entry and at a minimum of 3 months after entry; medical examination for the presence or absence of genital ulcer disease.
Overall, 758 heterosexual men with no history of injection drug use completed the study; HIV-1 seroconversion occurred in 10 of 344 (2.9%; 95% CI, 1.4% to 5.3%) men with a genital ulcer and in 4 of 414 (1%; CI, 0.2% to 2.5%) without a genital ulcer (relative risk, 3.0; P = 0.05). In a multiple logistic regression analysis, those men with chancroid and a new sexually transmitted disease during follow-up each had about three times the risk for HIV-1 seroconversion (P 0.04).
In this group of heterosexual men, chancroid and repeated acquisition of sexually transmitted diseases appeared to facilitate the sexual transmission of HIV-1.
Telzak EE, Chiasson MA, Bevier PJ, et al. HIV-1 Seroconversion in Patients with and without Genital Ulcer Disease: A Prospective Study. Ann Intern Med. 1993;119:1181–1186. doi: https://doi.org/10.7326/0003-4819-119-12-199312150-00005
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Published: Ann Intern Med. 1993;119(12):1181-1186.
HIV, Infectious Disease, Sexually Transmitted Infections.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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