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Letters |15 February 1994

Nitric Oxide Synthesis in Meningococcal Meningitis

Jelle J. Visser, PhD; Rob J. P. M. Scholten, MD; Klaas Hoekman, MD

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  • Free University Hospital; 1007 MB Amsterdam; The Netherlands
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TO THE EDITOR:
Clinical meningitis arises largely from the inflammatory response to bacteria invading the cerebrospinal fluid. Because nitric oxide, an endogenous mediator with vasodilator, neurotransmitter, and cytotoxic activities may be involved [1], we measured cerebrospinal fluid levels of nitrate and nitrite, the stable degradation products of nitric oxide, in 94 patients with meningococcal meningitis and in 44 patients with noninflammatory neurologic disease.
Controls had mean cerebrospinal fluid nitrate levels of 6.3 µmol/L (range, 2.3 to 17.3 µmol/L) and nitrite levels of 0.5 µmol/L (range, 0.4 to 1.7 µmol/L). Compared with controls, patients with meningitis had a mean nitrate...
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Visser JJ, Scholten RJPM, Hoekman K. Nitric Oxide Synthesis in Meningococcal Meningitis. Ann Intern Med. 1994;120:345–346. doi: 10.7326/0003-4819-120-4-199402150-00023

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Published: Ann Intern Med. 1994;120(4):345-346.

DOI: 10.7326/0003-4819-120-4-199402150-00023

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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