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Letters |15 April 1994

Morphine for Dyspnea in Patients with Cancer

Eduardo Bruera, MD; Robin L. Fainsinger, MBChB

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  • University of Alberta; Edmonton, Alberta T5K OL4; Canada
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IN RESPONSE:
We read with interest the letter by Krasnow and colleagues. Differences in results of pulse oximetry [1] and end-tidal CO2[2] after an increase of 50% in the analgesic dose of morphine may be due to differences in patient population or, more likely, to the mode of administration of morphine (intermittent injection compared with continuous infusion). Although some patients present with continuous dyspnea, most experience wide diurnal variations in the intensity of their dyspnea. The use of continuous opiates presents the same problems as that observed in the management of incident pain [3]: excessive dose when the symptom intensity is low and insufficient dose when it is high.
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Bruera E, Fainsinger RL. Morphine for Dyspnea in Patients with Cancer. Ann Intern Med. ;120:692–693. doi: 10.7326/0003-4819-120-8-199404150-00017

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Published: Ann Intern Med. 1994;120(8):692-693.

DOI: 10.7326/0003-4819-120-8-199404150-00017

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