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Letters |1 May 1994

Prevalence of HIV-1 Syncytium-inducing Phenotype

Michael J. Kozal, MD; Rani V. Ramachandran, MD; Robert W. Shafer, MD

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  • Stanford University Medical Center; Stanford, CA 94305
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TO THE EDITOR:
Koot and colleagues [1] reported that patients infected with human immunodeficiency virus (HIV) type 1 syncytium-inducing phenotype strains were more likely to progress to the acquired immunodeficiency syndrome (AIDS) than were patients with non-syncytium-inducing strains. Also, emergence of syncytium-inducing variants was associated with an accelerated CD4 cell decline, but it was not clear whether the relation was causal.
We agreed that it was important to know the prevalence of the syncytium-inducing phenotype, especially in patients enrolled in clinical trials, to guard against potential confounding by biased allocation of syncytium- and non-syncytium-inducing phenotypes. Consequently, we did a cross-sectional...
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Kozal MJ, Ramachandran RV, Shafer RW. Prevalence of HIV-1 Syncytium-inducing Phenotype. Ann Intern Med. 1994;120:811. doi: 10.7326/0003-4819-120-9-199405010-00019

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Published: Ann Intern Med. 1994;120(9):811.

DOI: 10.7326/0003-4819-120-9-199405010-00019

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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