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Letters |1 May 1994

Effects of Lovastatin and Pravastatin on Coronary Artery Disease

Mark R. Goldstein, MD

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Author, Article, and Disclosure Information
  • Crozer-Chester Medical Center; Upland, PA 19013
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TO THE EDITOR:
In comparing the Monitored Atherosclerosis Regression Study (MARS) [1] with another recently published coronary prevention trial that also tested reductase inhibitors against placebo, it appears that a decreased coronary event rate may be related to the particular reductase inhibitor.
The MARS trial was a randomized, double-blind, placebo-controlled, multicenter angiographic trial testing the effects of lovastatin on the progression of coronary artery disease in patients with angiographically proven coronary disease. Most patients had multiple risk factors for the disease. Treatment with diet and lovastatin (80 mg/d) for 2.2 years had a favorable effect on lipoprotein levels and angiographically proven coronary disease progression compared with diet and placebo. However, no statistical differences were noted between the placebo and lovastatin groups in regard to coronary events (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery surgery, coronary death, and unstable angina). Another randomized, double-blind, placebo-controlled multicenter trial tested pravastatin in persons with cholesterol levels of 5.2 to 7.8 mmol/L (200 to 300 mg/dL) and additional coronary risk factors [2]. Most had known coronary disease manifested by angina or previous myocardial infarction.
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Goldstein MR. Effects of Lovastatin and Pravastatin on Coronary Artery Disease. Ann Intern Med. ;120:811–812. doi: 10.7326/0003-4819-120-9-199405010-00020

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Published: Ann Intern Med. 1994;120(9):811-812.

DOI: 10.7326/0003-4819-120-9-199405010-00020

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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