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Letters |1 May 1994

Effects of Lovastatin and Pravastatin on Coronary Artery Disease

Mark R. Goldstein, MD

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  • Crozer-Chester Medical Center; Upland, PA 19013
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TO THE EDITOR:
In comparing the Monitored Atherosclerosis Regression Study (MARS) [1] with another recently published coronary prevention trial that also tested reductase inhibitors against placebo, it appears that a decreased coronary event rate may be related to the particular reductase inhibitor.
The MARS trial was a randomized, double-blind, placebo-controlled, multicenter angiographic trial testing the effects of lovastatin on the progression of coronary artery disease in patients with angiographically proven coronary disease. Most patients had multiple risk factors for the disease. Treatment with diet and lovastatin (80 mg/d) for 2.2 years had a favorable effect on lipoprotein levels and angiographically...
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Goldstein MR. Effects of Lovastatin and Pravastatin on Coronary Artery Disease. Ann Intern Med. 1994;120:811–812. doi: 10.7326/0003-4819-120-9-199405010-00020

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Published: Ann Intern Med. 1994;120(9):811-812.

DOI: 10.7326/0003-4819-120-9-199405010-00020

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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