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Letters |15 July 1994

Pitfalls in Measuring Cytokines

Samir Kapadia, MD; Guillermo Torre-Amione, MD, PhD; Douglas L. Mann, MD

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TO THE EDITOR:
Casey and colleagues [1] note the potential importance of measuring cytokine levels in patients with systemic sepsis, whereas Dinarello and Cannon [2] detail many of the pitfalls associated with assaying cytokine levels. We report some other difficulties inherent in measuring “immunoreactive” tumor necrosis factor (TNF)- α by enzyme-linked immunosorbent assay (ELISA). As noted by Casey and colleagues [1], the assessment of TNF-α immunoreactivity reflects the level of the biologically active and inactive forms of TNF-α. However, the level of immunoreactive TNF-α is greatly influenced by the type of monoclonal antibody used in the ELISA kit, as...
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Kapadia S, Torre-Amione G, Mann DL. Pitfalls in Measuring Cytokines. Ann Intern Med. 1994;121:149–150. doi: 10.7326/0003-4819-121-2-199407150-00016

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Published: Ann Intern Med. 1994;121(2):149-150.

DOI: 10.7326/0003-4819-121-2-199407150-00016

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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