Skip Navigation
Menu
Editorials |15 December 1994

Clarithromycin Therapy for Mycobacterium avium Complex Disease in Patients with AIDS: Potential and Problems

Mark Goldberger, MD; Henry Masur, MD

Article, Author, and Disclosure Information
Author, Article, and Disclosure Information
Copyright ©2004 by the American College of Physicians
2004
  • Food and Drug Administration; Rockville, MD 20857 National Institutes of Health; Bethesda, MD 20892-1662 Disclaimer: This article represents the views of the authors and does not represent official policy of the National Institutes of Health or the Food and Drug Administration.
×
FULL TEXT
The quality and duration of survival for patients with human immunodeficiency virus (HIV) infection have improved substantially during the past decade. Much of this improvement has been because of better management of opportunistic infections. However, progress with Mycobacterium avium complex, a pathogen that ultimately infects 30% to 50% of patients with the acquired immunodeficiency syndrome (AIDS) in North America, has until recently been disappointing, especially in terms of prophylaxis and therapy.
The development of new rifamycin and macrolide antibiotics has increased optimism among health care providers and patients searching for remedies for disease caused by this Mycobacterium species. Rifabutin, a newer rifamycin, has been approved by the U.S. Food and Drug Administration for prophylaxis of M. avium complex based on two large, controlled trials [1]. Clarithromycin, a newer macrolide, is the only drug that has been approved to date for the acute treatment of disseminated M. avium complex disease. This approval was based largely on unpublished data (2, 3; Minutes of the Open Public Meeting of the Food and Drug Administration Antiviral Advisory Committee, 10 May 1993). For health care professionals and patients, an important question is, “Do we truly have therapy that can produce sustained clinical benefit?”
FULL TEXT
PDF
Not Available
Citations
Citation

Goldberger M, Masur H. Clarithromycin Therapy for Mycobacterium avium Complex Disease in Patients with AIDS: Potential and Problems. Ann Intern Med. 1994;121:974–976. doi: 10.7326/0003-4819-121-12-199412150-00012

Download citation file:

© 2019

×
Permissions

Published: Ann Intern Med. 1994;121(12):974-976.

DOI: 10.7326/0003-4819-121-12-199412150-00012

11 Citations

Related Articles
Clarithromycin Therapy for Bacteremic Mycobacterium avium Complex Disease: A Randomized, Double-Blind, Dose-Ranging Study in Patients with AIDS
Annals of Internal Medicine; 121 (12): 905-911
Treatment of Disseminated Mycobacterium avium Complex Infection in AIDS with Amikacin, Ethambutol, Rifampin, and Ciprofloxacin
Annals of Internal Medicine; 113 (5): 358-361
Acquired Immunodeficiency Syndrome with Pneumocystis carinii Pneumonia and Mycobacterium avium-intracellulare Infection in a Previously Healthy Patient with Classic Hemophilia: Clinical, Immunologic, and Virologic Findings
Annals of Internal Medicine; 98 (3): 287-290
Statin Toxicity From Macrolide Antibiotic Coprescription: A Population-Based Cohort Study
Annals of Internal Medicine; 158 (12): 869-876
View MoreView Less

Related Topics
Infectious Disease

Infectious Disease.

PubMed Articles
Comparison of in vitro synergistic effect between clarithromycin and azithromycin in combination with amikacin against Mycobacterium intracellulare.
J Glob Antimicrob Resist 2019.
Central Nervous System Vasculitis Due to Substance Abuse.
Neurol Clin 2019;37(2):425-440.
View More

Results provided by: PubMed

CONTINUE WITH LIMITED ACCESS
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
acp link acp
silverchair link silverchair

Copyright © 2019 American College of Physicians. All Rights Reserved.

Print ISSN: 0003-4819 | Online ISSN: 1539-3704

Privacy Policy

|

Conditions of Use

This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy. | Accept
×

You need a subscription to this content to use this feature.

×
PDF Downloads Require Access to the Full Article.
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
Access to this Free Content Requires Users to be Registered and Logged In. Please Choose One of the Following Options
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×