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Letters |15 April 1995

Prophylaxis for Stress-Related Gastric Hemorrhage

Jeffrey N. Martin

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TO THE EDITOR:
In their article on the prophylaxis of stress-related gastric hemorrhage, Ben-Menachem and coworkers [1] discuss several potential explanations for their finding of lack of efficacy of either cimetidine or sucralfate. Although alluded to in the discussion, the study's low statistical power deserves further elaboration.
The determination that 160 patients would be required in each treatment arm to provide 80% power to detect a 75% reduction in bleeding from a baseline rate of 12% is statistically correct [2]. A 75% reduction, however, may be overly optimistic for sample size calculations. Using the concepts of Goodman and Berlin...
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Martin JN. Prophylaxis for Stress-Related Gastric Hemorrhage. Ann Intern Med. 1995;122:632–634. doi: 10.7326/0003-4819-122-8-199504150-00024

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Published: Ann Intern Med. 1995;122(8):632-634.

DOI: 10.7326/0003-4819-122-8-199504150-00024

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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