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Letters |1 May 1995

Low-Dose Interferon-α in Chronic Myeloid Leukemia

Moshe Talpaz; Hagop Kantarjian

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TO THE EDITOR:
We read with great interest the excellent report by Schofield and colleagues [1] on the efficacy of low-dose interferon-α in patients with chronic myeloid leukemia. In this study, 41 patients with Philadelphia chromosome (Ph)-positive chronic myeloid leukemia received interferon-α maintenance therapy, 2 × 106 U/m2 body surface area three times a week. The complete hematologic response rate was 70%, the major cytogenetic response rate was 22%, and the median survival from the time of diagnosis was 84 months; these figures compared favorably with the historical experience with hydroxyurea therapy.
Although these results confirm our original data, we disagree with the conclusion that low-dose interferon-α is as effective as higher doses. The conclusions were based on comparison of the small sample of 27 patients with early-phase chronic myeloid leukemia.
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Talpaz M, Kantarjian H. Low-Dose Interferon-α in Chronic Myeloid Leukemia. Ann Intern Med. ;122:728–729. doi: 10.7326/0003-4819-122-9-199505010-00013

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Published: Ann Intern Med. 1995;122(9):728-729.

DOI: 10.7326/0003-4819-122-9-199505010-00013

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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