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Letters |1 June 1995

Recurrence Rates of Genital Herpes

Lawrence Corey; Jacqueline Benedetti; Rhoda Ashley

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Author, Article, and Disclosure Information
  • Royal Perth Hospital, Perth, Western Australia 6001, Australia. University of Washington School of Medicine, Seattle, WA 98144.
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IN RESPONSE:
Drs. Marshall and Purnell are correct that our study group had a low seroprevalence of HSV-1 infection. Most serosurveys suggest that approximately half of the persons with HSV-2 antibody also have HSV-1 antibodies [1]. In our cohort of patients with a first episode of genital herpes, only 13% were seropositive for HSV-1 infection. As we have shown [2], previous HSV-1 infection lessens the severity of HSV-2 infection and increases the frequency of unrecognized genital HSV infection. As such, we would expect this distribution of HSV antibodies in a study designed to evaluate the natural history of first-episode infections that are clinically symptomatic. One of the points of our paper was that previous HSV-1 infection, although it influences the clinical severity of the first episode, does not appear to influence the subsequent frequency of clinical reactivations of HSV-2 infection, at least during the initial years of disease observation [3]. The subclinical shedding rates among persons seropositive for HSV-2 and those who are seropositive for HSV-1 and HSV-2 are also similar [4].
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Corey L, Benedetti J, Ashley R. Recurrence Rates of Genital Herpes. Ann Intern Med. ;122:883. doi: 10.7326/0003-4819-122-11-199506010-00025

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Published: Ann Intern Med. 1995;122(11):883.

DOI: 10.7326/0003-4819-122-11-199506010-00025

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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