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Letters |1 July 1995

The Chronic Fatigue Syndrome

Jonathan Rest, MD

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Author, Article, and Disclosure Information
  • University of California, San Francisco; San Francisco, CA 94122
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TO THE EDITOR:
The development of an effective new case definition for the chronic fatigue syndrome poses a unique challenge because of the protean nature of fatigue and its accompanying symptoms. Unfortunately, the 1988 case definition failed to identify a unique disease entity (Hickie and colleagues; Reyes and colleagues. Unpublished data). Although the case criteria suggested by Fukuda and colleagues [1] address many of the shortcomings of the 1988 research definition, the clinical and social need for a definitive diagnostic tool remains largely unmet.
Although the previous research case definition was a significant step forward, its clinical implications were unanticipated. Many physicians were left wondering whether their patients had the syndrome or not. Many patients were denied benefits because they did not “make the diagnosis.”
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Rest J. The Chronic Fatigue Syndrome. Ann Intern Med. ;123:74–76. doi: 10.7326/0003-4819-123-1-199507010-00016

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Published: Ann Intern Med. 1995;123(1):74-76.

DOI: 10.7326/0003-4819-123-1-199507010-00016

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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