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Letters |1 July 1995

The Chronic Fatigue Syndrome

Jonathan Rest, MD

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  • University of California, San Francisco; San Francisco, CA 94122
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TO THE EDITOR:
The development of an effective new case definition for the chronic fatigue syndrome poses a unique challenge because of the protean nature of fatigue and its accompanying symptoms. Unfortunately, the 1988 case definition failed to identify a unique disease entity (Hickie and colleagues; Reyes and colleagues. Unpublished data). Although the case criteria suggested by Fukuda and colleagues [1] address many of the shortcomings of the 1988 research definition, the clinical and social need for a definitive diagnostic tool remains largely unmet.
Although the previous research case definition was a significant step forward, its clinical implications were unanticipated....
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Rest J. The Chronic Fatigue Syndrome. Ann Intern Med. 1995;123:74–76. doi: 10.7326/0003-4819-123-1-199507010-00016

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Published: Ann Intern Med. 1995;123(1):74-76.

DOI: 10.7326/0003-4819-123-1-199507010-00016

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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