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Letters |1 July 1995

Insulin-Like Growth Factors and Hematologic Malignancies

Ilan Shimon, MD; Ofer Shpilberg, MD

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  • Cedars-Sinai Medical Center; Los Angeles, CA 90048-1865 University of Pittsburgh; Pittsburgh, PA 15261
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TO THE EDITOR:
In their excellent review on the family of insulin-like growth factors (IGF) and cancer, LeRoith and colleagues [1] described the current knowledge of the role of the IGFs and of their receptors and binding proteins in certain solid tumors. However, the authors did not mention the involvement of the IGF system in the growth and development of neoplastic hematologic processes. We recently reviewed the relevant literature on the role of the IGF system in the regulation of normal and malignant hematopoiesis [2]. Nearly all hematopoietic cells, either normal or neoplastic, express the receptors of IGF, and...
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Shimon I, Shpilberg O. Insulin-Like Growth Factors and Hematologic Malignancies. Ann Intern Med. 1995;123:76. doi: https://doi.org/10.7326/0003-4819-123-1-199507010-00020

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Published: Ann Intern Med. 1995;123(1):76.

DOI: 10.7326/0003-4819-123-1-199507010-00020

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