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Letters |15 July 1995

Treatment of the Hypereosinophilic Syndrome with Interferon-α

Joseph H. Butterfield, MD; Gerald J. Gleich, MD

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We read with interest the letter by Papo and colleagues. Although it is difficult to make a generalization on the basis of a brief case report, we hesitate to call their experience a clinical failure because of the apparent low dose of interferon-α used (5 MU three times a week). In our experience, the dose of interferon-α necessary for initial control of the hypereosinophilic syndrome has been as high as 8 MU/d. This dose can often subsequently be decreased. Among many patients in our study, we noted a wide dose range that was initially necessary for control of eosinophilia. We emphasize the importance of tailoring each recipient's dose and stress that a daily dose of interferon-α may be necessary to control eosinophilia.
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Butterfield JH, Gleich GJ. Treatment of the Hypereosinophilic Syndrome with Interferon-α. Ann Intern Med. ;123:156. doi: 10.7326/0003-4819-123-2-199507150-00032

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Published: Ann Intern Med. 1995;123(2):156.

DOI: 10.7326/0003-4819-123-2-199507150-00032

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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