John I. Gallin; Joshua M. Farber; Steven M. Holland; Thomas B. Nutman
Interferon-γ has pleiotropic adjuvant effects on host defenses. These effects have made interferon-γ particularly useful for enhancing host defenses in patients with chronic granulomatous disease of childhood and thus for reducing the incidence of life-threatening infections in these patients. Increasingly, data suggest that interferon-γ will be useful for treating infections characterized by intracellular persistence in macrophages, such as toxoplasmosis, leishmaniasis, and mycobacteriosis. Interferon-γ is emerging as an important cytokine for use in the treatment of infectious diseases.
Gallin JI, Farber JM, Holland SM, et al. Interferon-γ in the Management of Infectious Diseases. Ann Intern Med. 1995;123:216–224. doi: https://doi.org/10.7326/0003-4819-123-3-199508010-00009
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Published: Ann Intern Med. 1995;123(3):216-224.
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