Skip Navigation
Menu
Letters |1 September 1995

Minocycline in Rheumatoid Arthritis

Richard Meehan, MD

Article, Author, and Disclosure Information
Author, Article, and Disclosure Information
  • University of Colorado Health Sciences Center; Denver, CO 80262
×
FULL TEXT
TO THE EDITOR:
The extremely well-designed study by Tilley and colleagues [1] has many features that should allow the authors to detect a statistically significant difference between placebo and drug treatment groups. The authors successfully showed a benefit (albeit small [54% compared with 39%]) in the drug treatment group. However, they did not report additional specific information on the corticosteroid dose and the specific nonsteroidal agent received in both groups or on the changes that could have developed between the control and treatment groups over time. Specifically, was there a statistically significant difference between objective variables such as joint swelling before and after the trial in the patients in both groups whose corticosteroid dose or nonsteroidal agent did not change? Perhaps a similar trial without protocol violations could compare minocycline with standard drugs used to treat patients with mild to moderate rheumatoid arthritis, such as plaquenil, azulfidine, or oral gold. Such a study would allow clinicians to determine whether this therapy might have a practical clinical role in managing patients with early, mild rheumatoid arthritis.
FULL TEXT
PDF
Not Available
Citations
Citation

Meehan R. Minocycline in Rheumatoid Arthritis. Ann Intern Med. ;123:391. doi: 10.7326/0003-4819-123-5-199509010-00018

Download citation file:

© 2019

×
Permissions

Published: Ann Intern Med. 1995;123(5):391.

DOI: 10.7326/0003-4819-123-5-199509010-00018

0 Citations
CONTINUE WITH LIMITED ACCESS
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
acp link acp
silverchair link silverchair

Copyright © 2019 American College of Physicians. All Rights Reserved.

Print ISSN: 0003-4819 | Online ISSN: 1539-3704

Privacy Policy

|

Conditions of Use

This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy. | Accept
×

You need a subscription to this content to use this feature.

×
PDF Downloads Require Access to the Full Article.
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
Access to this Free Content Requires Users to be Registered and Logged In. Please Choose One of the Following Options
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×