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Letters |1 September 1995

Minocycline in Rheumatoid Arthritis

Stephen P. Heyse, MD, MPH; Barbara C. Tilley, PhD; Graciela S. Alarcon, MD, MPH

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Author, Article, and Disclosure Information
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases; Bethesda, MD 20892 Henry Ford Health Sciences Center; Detroit, MI 48202 University of Alabama at Birmingham; Birmingham, AL 35294
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IN RESPONSE:
We agree with Dr. Patmas that minocycline's mechanism of action in producing benefit in patients with rheumatoid arthritis is unknown; however, we do not believe that any of the patients enrolled in our trial were infected with Borrelia burgdorferi. To be eligible for the study of ceftriaxone treatment of chronic inflammatory arthritis cited by Dr. Patmas, patients had to have antibodies to B. burgdorferi in titers of 1:64 or greater on two occasions before entry. We actively excluded patients with a history or clinical evidence of Lyme disease, and all patients tested negative for antibodies to B....
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Heyse SP, Tilley BC, Alarcon GS. Minocycline in Rheumatoid Arthritis. Ann Intern Med. 1995;123:392. doi: 10.7326/0003-4819-123-5-199509010-00020

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Published: Ann Intern Med. 1995;123(5):392.

DOI: 10.7326/0003-4819-123-5-199509010-00020

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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