Skip Navigation
Menu
Letters |1 September 1995

Minocycline in Rheumatoid Arthritis

Stephen P. Heyse, MD, MPH; Barbara C. Tilley, PhD; Graciela S. Alarcon, MD, MPH

Article, Author, and Disclosure Information
Author, Article, and Disclosure Information
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases; Bethesda, MD 20892 Henry Ford Health Sciences Center; Detroit, MI 48202 University of Alabama at Birmingham; Birmingham, AL 35294
×
FULL TEXT
IN RESPONSE:
We agree with Dr. Patmas that minocycline's mechanism of action in producing benefit in patients with rheumatoid arthritis is unknown; however, we do not believe that any of the patients enrolled in our trial were infected with Borrelia burgdorferi. To be eligible for the study of ceftriaxone treatment of chronic inflammatory arthritis cited by Dr. Patmas, patients had to have antibodies to B. burgdorferi in titers of 1:64 or greater on two occasions before entry. We actively excluded patients with a history or clinical evidence of Lyme disease, and all patients tested negative for antibodies to B. burgdorferi on serum samples collected at the baseline evaluation and assayed by the Centers for Disease Control and Prevention.
FULL TEXT
PDF
Not Available
Citations
Citation

Heyse SP, Tilley BC, Alarcon GS. Minocycline in Rheumatoid Arthritis. Ann Intern Med. ;123:392. doi: 10.7326/0003-4819-123-5-199509010-00020

Download citation file:

© 2019

×
Permissions

Published: Ann Intern Med. 1995;123(5):392.

DOI: 10.7326/0003-4819-123-5-199509010-00020

0 Citations
CONTINUE WITH LIMITED ACCESS
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
acp link acp
silverchair link silverchair

Copyright © 2019 American College of Physicians. All Rights Reserved.

Print ISSN: 0003-4819 | Online ISSN: 1539-3704

Privacy Policy

|

Conditions of Use

This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy. | Accept
×

You need a subscription to this content to use this feature.

×
PDF Downloads Require Access to the Full Article.
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
Access to this Free Content Requires Users to be Registered and Logged In. Please Choose One of the Following Options
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×