Skip Navigation
Menu
Original Research |15 October 1995

Transient Cortical Blindness and Bioccipital Brain Lesions in Two Patients with Acute Intermittent Porphyria

Hugo Kupferschmidt, MD; Adriano Bont, MD; Hans Schnorf, MD; Theodor Landis, MD; Eike Walter, MD; Jurg Peter, MD; Stephan Krahenbuhl, MD, PharmD; Peter J. Meier, MD

Article, Author, and Disclosure Information
Author, Article, and Disclosure Information
Copyright ©2004 by the American College of Physicians
2004
  • From University Hospital, Zurich; University Hospital, Basel; and University Hospital, Geneva, Switzerland. Requests for Reprints: Peter J. Meier, MD, Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital CH-8091, Zurich, Switzerland. Current Author Addresses: Drs. Kupferschmidt, Krahenbuhl, and Meier: Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, CH-8091, Zurich, Switzerland.
×
FULL TEXT
The most common neurologic manifestations of acute intermittent porphyria are autonomic visceral neuropathy, peripheral motor neuropathy, and central nervous system dysfunctions, including seizures and neuropsychiatric disturbances [1]. In rare instances, however, patients with acute intermittent porphyria have presented with acute cortical blindness [2-5], for which deleterious vasospasm in both posterior cerebral arteries has been inferred [3, 6].
We describe two patients in whom cortical blindness was the first symptom of acute intermittent porphyria. Magnetic resonance imaging showed extensive lesions involving primarily white matter of both occipital lobes consistent with vasospasm-induced ischemic lesions. However, the pathogenesis of the...
FULL TEXT
PDF
Not Available
Citations
Citation

Kupferschmidt H, Bont A, Schnorf H, Landis T, Walter E, Peter J, et al. Transient Cortical Blindness and Bioccipital Brain Lesions in Two Patients with Acute Intermittent Porphyria. Ann Intern Med. 1995;123:598–600. doi: 10.7326/0003-4819-123-8-199510150-00006

Download citation file:

© 2019

×
Permissions

Published: Ann Intern Med. 1995;123(8):598-600.

DOI: 10.7326/0003-4819-123-8-199510150-00006

75 Citations

Related Articles
Recommendations for the Diagnosis and Treatment of the Acute Porphyrias
Annals of Internal Medicine; 142 (6): 439-450
Relation between Directly Detected Patent Foramen Ovale and Ischemic Brain Lesions in Sport Divers
Annals of Internal Medicine; 134 (1): 21-24
Brain Lesions in Scuba Divers
Annals of Internal Medicine; 134 (1): I-67
Evaluating Contrast-Enhancing Brain Lesions in Patients with AIDS by Using Positron Emission Tomography
Annals of Internal Medicine; 123 (8): 594-598
View MoreView Less

Related Point of Care
Venous Leg Ulcers
Annals of Internal Medicine; 165 (3): ITC17-ITC32
View MoreView Less

Related Topics
Gastroenterology/Hepatology
Liver Disease
Neurology

Gastroenterology/Hepatology, Liver Disease, Neurology.

PubMed Articles
A new era for rare genetic diseases.
Hum Gene Ther 2019.
Impact of acute intraocular pressure elevation on the visual acuity of non-human primates.
EBioMedicine 2019.
View More

Results provided by: PubMed

CONTINUE WITH LIMITED ACCESS
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
acp link acp
silverchair link silverchair

Copyright © 2019 American College of Physicians. All Rights Reserved.

Print ISSN: 0003-4819 | Online ISSN: 1539-3704

Privacy Policy

|

Conditions of Use

This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy. | Accept
×

You need a subscription to this content to use this feature.

×
PDF Downloads Require Access to the Full Article.
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
Access to this Free Content Requires Users to be Registered and Logged In. Please Choose One of the Following Options
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×