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Letters |15 November 1995

SIADH in a Patient Receiving Sertraline

Daniel D. Bluff, MD; Ngozi Oji, MD

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  • St. John's Episcopal Hospital; Far Rockaway, NY 11691
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TO THE EDITOR:
Selective serotonin re-uptake inhibitors are better tolerated than older antidepressant agents but are associated with side effects of which internists may not be aware. One such side effect is the syndrome of inappropriate antidiuretic hormone secretion (SIADH). Life-threatening hyponatremia due to SIADH has been described with both fluoxetine (Prozac, Dista Products Co., Indianapolis, Indiana) [1] and paroxetine (Paxil, SmithKline Beecham Pharmaceuticals, Pittsburgh, Pennsylvania) [2]. Recently, several reports in the psychiatric literature have described the occurrence of SIADH due to another selective serotonin reuptake inhibitor, sertraline (Zoloft, Roerig, New York, New York) [3-5]. We describe an additional case of sertraline-induced life-threatening hyponatremia and wish to alert internists to this possible complication.
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Bluff DD, Oji N. SIADH in a Patient Receiving Sertraline. Ann Intern Med. ;123:811. doi: 10.7326/0003-4819-123-10-199511150-00024

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Published: Ann Intern Med. 1995;123(10):811.

DOI: 10.7326/0003-4819-123-10-199511150-00024

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