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Letters |15 March 1996

Induction of Adrenal Suppression by Megestrol Acetate

Sheldon S. Stoffer, MD; Jesse C. Krakauer, MD

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Author, Article, and Disclosure Information
  • Oakland Internists and Associates; Southfield, MI 48034
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TO THE EDITOR:
The recent article by Leinung and colleagues [1] is of great public health importance in showing that megestrol acetate, a progestational agent, can suppress the pituitary-adrenal axis and result in secondary adrenal insufficiency. This information is not currently included in the Physicians' Desk Reference and remains largely unknown to prescribing physicians.
We describe a 52-year-old woman who was referred for possible adrenal insufficiency. She had had lumpectomy in 1988, followed by radiation therapy and chemotherapy for breast cancer. Because a bone scan suggested involvement of vertebrae T11 and L1, the patient received radiation therapy to the back in 1994. She began receiving megestrol acetate (40 mg, four times daily) 6 months before evaluation.
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Stoffer SS, Krakauer JC. Induction of Adrenal Suppression by Megestrol Acetate. Ann Intern Med. 1996;124:613–614. doi: 10.7326/0003-4819-124-6-199603150-00018

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Published: Ann Intern Med. 1996;124(6):613-614.

DOI: 10.7326/0003-4819-124-6-199603150-00018

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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