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Letters |1 April 1996

Preemptive Ganciclovir Therapy in Renal Transplantation

Daniel C. Brennan, MD; Gregory A. Storch, MD; Bruce J. Lippman, MD

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  • Washington University School of Medicine; St. Louis, MO 63110
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TO THE EDITOR:
Hibberd and colleagues [1] recently showed that administration of ganciclovir during antilymphocyte therapy in renal transplant recipients who tested positive for cytomegalovirus (CMV) antibody decreased the incidence of CMV disease. They called this treatment strategy “preemptive therapy.” We believe that a more accurate term would have been “selected prophylactic therapy.”
The term “prophylaxis” connotes the use of an agent to prevent disease in patients at risk when no evidence suggests the imminent development of that disease. Thus, we use antibiotics for endocarditis prophylaxis when a patient with a heart murmur (but no overt evidence of bacteremia) has...
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Brennan DC, Storch GA, Lippman BJ. Preemptive Ganciclovir Therapy in Renal Transplantation. Ann Intern Med. 1996;124:693. doi: 10.7326/0003-4819-124-7-199604010-00015

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Published: Ann Intern Med. 1996;124(7):693.

DOI: 10.7326/0003-4819-124-7-199604010-00015

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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