Skip Navigation
Menu
Letters |15 June 1996

Interferon-γ and Management of Infectious Diseases

Steven M. Holland, MD; Joshua M. Farber, MD; John I. Gallin, MD

Article, Author, and Disclosure Information
Author, Article, and Disclosure Information
  • National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bethesda, MD 20189
×
FULL TEXT
IN RESPONSE:
We agree with Baier-Bitterlich and colleagues that the mechanism by which interferon-γ acts in the setting of chronic infections such as leishmaniasis or tuberculosis is complex and may not fit neatly into the TH1/TH2 paradigm. Feedback loops, such as that which includes prostaglandin E2, are known to be down-regulatory for the destruction of intracellular pathogens at the macrophage level and are overcome by pharmacologic interferon-γ administration [1]. Similarly, interleukin-6 has been shown to down-regulate macrophage tumor necrosis factor-α receptor levels and to antagonize the interferon-γ-induced up-regulation of tumor necrosis factor-α receptor levels [2]...
FULL TEXT
PDF
Not Available
Citations
Citation

Holland SM, Farber JM, Gallin JI. Interferon-γ and Management of Infectious Diseases. Ann Intern Med. 1996;124:1095–1096. doi: https://doi.org/10.7326/0003-4819-124-12-199606150-00016

Download citation file:

© 2020

×
Permissions

Published: Ann Intern Med. 1996;124(12):1095-1096.

DOI: 10.7326/0003-4819-124-12-199606150-00016

0 Citations
CONTINUE WITH LIMITED ACCESS
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
acp link acp
silverchair link silverchair

Copyright © 2020 American College of Physicians. All Rights Reserved.

Print ISSN: 0003-4819 | Online ISSN: 1539-3704

Privacy Policy

|

Conditions of Use

This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy. | Accept
×

You need a subscription to this content to use this feature.

×
PDF Downloads Require Access to the Full Article.
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
Access to this Free Content Requires Users to be Registered and Logged In. Please Choose One of the Following Options
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×