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Letters |15 February 1997

Serotonin Reuptake Inhibitor Unmasks a Pheochromocytoma

Marc A.J. Seelen, MD; Paul H.E.M. de Meijer, MD, PhD; A. Edo Meinders, MD, PhD

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  • University Hospital Leiden, 2300 RC Leiden, the Netherlands
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TO THE EDITOR:
We describe a 55-year-old man with attacks of headache, nausea, palpitations, and perspiration after the dose of paroxetine (a serotonin reuptake inhibitor prescribed for depression) was doubled to 40 mg/d. His other medications were atenolol and a benzodiazepine. Physical examination showed that the patient was agitated and had striking peripheral vasoconstriction. Blood pressure varied between 240/130 and 80/40 mm Hg; the patient did not have orthostatic hypotension. Because of the patient's paroxysmal symptoms and striking changes in blood pressure, a pheochromocytoma was suspected. A 24-hour urinalysis showed noradrenalin, 9.2 nmol (normal, 0.06 to 0.47 nmol); adrenalin, 27...
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Seelen MA, de Meijer PH, Meinders AE. Serotonin Reuptake Inhibitor Unmasks a Pheochromocytoma. Ann Intern Med. 1997;126:333. doi: https://doi.org/10.7326/0003-4819-126-4-199702150-00021

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Published: Ann Intern Med. 1997;126(4):333.

DOI: 10.7326/0003-4819-126-4-199702150-00021

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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