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Letters |15 March 1997

Treatment of Behcet Disease with Pentoxifylline

Jedd D. Wolchok, MD, PhD

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  • Memorial Sloan-Kettering Cancer Center, New York, NY 10021
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TO THE EDITOR:
Yasui and colleagues [1] recently published an interesting report on the efficacy of pentoxifylline in the treatment of three patients with Behcet disease. The precise cause of Behcet disease remains unknown; however, international diagnostic criteria include the classic symptoms of oral and genital ulcerations, uveitis, and skin lesions [2].
I was intrigued by one possible mechanism of action of pentoxifylline that may help elucidate the cause of Behcet disease. This compound, a methylxanthine derivative, has been shown to inhibit the production of various proinflammatory cytokines, especially tumor necrosis factor-α (TNF-α) [3]. Interestingly, levels of TNF-α...
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Wolchok JD. Treatment of Behcet Disease with Pentoxifylline. Ann Intern Med. 1997;126:493. doi: 10.7326/0003-4819-126-6-199703150-00020

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Published: Ann Intern Med. 1997;126(6):493.

DOI: 10.7326/0003-4819-126-6-199703150-00020

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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