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Letters |15 May 1997

Response to Activated Protein C and Cerebrovascular Disease

Matthew P. Jones, MD; Barbara Alving, MD

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  • Walter Reed Army Medical Center, Washington, DC 20307-5001 Washington Hospital Center, Washington, DC 20010
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TO THE EDITOR:
The most common inherited hypercoagulable state results from a mutation in factor V (factor V Leiden, 1691G → A), which causes factor Va to be “resistant” to inhibition by activated protein C (APC). This disorder is evaluated by a plasma assay that measures the ratio of the activated partial thromboplastin time with and without APC or by DNA analysis for the single point mutation of the factor V gene. A major goal of hemostasis laboratories has been to develop a plasma assay for resistance to APC that is sensitive and specific for factor V Leiden, as assessed by the genomic assay. The current recommendation is to perform all assays by premixing patient plasma with factor V-deficient plasma in order to enhance sensitivity and specificity [1, 2].
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Jones MP, Alving B. Response to Activated Protein C and Cerebrovascular Disease. Ann Intern Med. ;126:832–833. doi: 10.7326/0003-4819-126-10-199705150-00034

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Published: Ann Intern Med. 1997;126(10):832-833.

DOI: 10.7326/0003-4819-126-10-199705150-00034

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