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Original Research |1 June 1997

Complete Sustained Response of a Refractory, Post-Transplantation, Large B-Cell Lymphoma to an Anti-CD22 Immunotoxin

Adrian M. Senderowicz, MD; Ellen Vitetta, PhD; Donna Headlee, RN; Victor Ghetie, PhD; Jonathan W. Uhr, MD; William D. Figg, PharmD; Richard M. Lush, PhD; Maryalice Stetler-Stevenson, MD, PhD; Glenn Kershaw, MD; Douglas W. Kingma, MD; Elaine S. Jaffe, MD; Edward A. Sausville, MD, PhD

Article, Author, and Disclosure Information
Author, Article, and Disclosure Information
Copyright ©2004 by the American College of Physicians
2004
  • From the National Cancer Institute, National Institutes of Health, Bethesda, Maryland; University of Massachusetts Medical Center, Worcester, Massachusetts; and University of Texas Southwestern Medical Center, Dallas, Texas. Grant Support: Extramural portions of the study were supported by National Institutes of Health grants CA28149 and CA41081. Requests for Reprints: Edward A. Sausville, MD, PhD, Developmental Therapeutics Program, National Cancer Institute, Executive Plaza North, Suite 843, 6130 Executive Boulevard, Rockville, MD 20852. Current Author Addresses: Dr. Senderowicz and Ms. Headlee: Medicine Branch, Division of Clinical Science, National Cancer Institute, National Institutes of Health, Building 10, Room 12N226, 9000 Rockville Pike, Bethesda, MD 20892.
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CD19, CD20, CD21, CD22: B-cell surface markers frequently expressed on the surface of B-cell tumors. The immunotoxin used in our patient is directed against CD22.
EBER-1: Epstein-Barr encoded RNA.
Immunotoxin: A drug formed by chemical linkage of an antibody to a toxin.
RFB4-dgA: The immunotoxin used in our patient; it consists of the murine monoclonal antibody RFB4, which is linked to the deglycosylated A-chain of ricin, a plant toxin.
Vascular leak syndrome: A side effect of immunotoxin treatment that consists of nontargeted damage to endothelial cells and manifests as hypoalbuminemia and edema in its mild form.
Transplant recipients have an...
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Senderowicz AM, Vitetta E, Headlee D, Ghetie V, Uhr JW, Figg WD, et al. Complete Sustained Response of a Refractory, Post-Transplantation, Large B-Cell Lymphoma to an Anti-CD22 Immunotoxin. Ann Intern Med. 1997;126:882–885. doi: 10.7326/0003-4819-126-11-199706010-00005

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Published: Ann Intern Med. 1997;126(11):882-885.

DOI: 10.7326/0003-4819-126-11-199706010-00005

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