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Letters |15 July 1997

Pregnancy-Related Thromboembolism

Martin H. Prins, MD, PhD

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Author, Article, and Disclosure Information
  • Academic Medical Center, University of Amsterdam; Amsterdam, the Netherlands
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IN RESPONSE:
Dr. Manoharan addresses the important issue of the use of a drug when there is no formal knowledge of safety in a specific situation. The experience with low-molecular-weight heparin in pregnancy was obtained while the pharmaceutical companies advised against use of the drug during pregnancy [1, 2]. One report has indicated that low-molecular-weight heparin, like unfractionated heparin, does not appear in breast milk [3]. Moreover, heparin is not easily absorbed and thus when given orally is unlikely to cause any adverse effects.
We thank Brickner and colleagues for pointing out a mathematical error that escaped our attention when we reviewed the galley proofs of our article. The numbers in the second paragraph of the introduction should read 0.018%, 0.013% to 0.07%, and 0.061% to 0.23%, respectively. Thus, Brickner and colleagues' findings agree with the existing literature on the incidence of pregnancy-related venous thromboembolism in the general population.
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Prins MH. Pregnancy-Related Thromboembolism. Ann Intern Med. ;127:164. doi: 10.7326/0003-4819-127-2-199707150-00020

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Published: Ann Intern Med. 1997;127(2):164.

DOI: 10.7326/0003-4819-127-2-199707150-00020

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Print ISSN: 0003-4819 | Online ISSN: 1539-3704

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