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Letters |15 September 1997

Transdermal Nicotine for Ulcerative Colitis: Reply

William J. Sandborn, MD; William J. Tremaine, MD; Richard D. Hurt, MD

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  • Mayo Clinic; Rochester, MN 55905
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IN RESPONSE:
Drs. Mogadam, Ando, and Guslandi and Tittobello raise many interesting points. Dr. Mogadam states that a 30% response (39% for nicotine compared with 9% for placebo) is not clinically meaningful. We strongly disagree. Studies of drugs that we accept as efficacious for ulcerative colitis and that led to U.S. Food and Drug Administration approval had very similar response rates. For example, Asacol (mesalamine, Procter & Gamble, Inc., Cincinnati, Ohio) at 2.4 g/d showed 26% clinical improvement (49% for Asacol and 23% for placebo) [1], and Pentasa (mesalamine, Hoechst Marion Roussel, Kansas City, Missouri) at 4.0 g/d showed...
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Sandborn WJ, Tremaine WJ, Hurt RD. Transdermal Nicotine for Ulcerative Colitis: Reply. Ann Intern Med. 1997;127:492. doi: 10.7326/0003-4819-127-6-199709150-00021

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Published: Ann Intern Med. 1997;127(6):492.

DOI: 10.7326/0003-4819-127-6-199709150-00021

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