Montserrat Ferrer, MD, MPH; Jordi Alonso, MD, PhD; Josep Morera, MD, PhD; Ramon M. Marrades, MD; Ahmad Khalaf, MD; M. Carmen Aguar, MD, PhD; Vicente Plaza, MD, PhD; Luis Prieto, PhD; Josep M. Anto, MD, PhD
The American Thoracic Society recently recommended that chronic obstructive pulmonary disease be staged on the basis of the percentage of predicted FEV1.
To examine 1) the relation between the American Thoracic Society system for staging chronic obstructive pulmonary disease and health-related quality of life and 2) the effect of self-reported comorbid conditions on health-related quality of life.
Outpatient clinics of respiratory department of four hospitals and one primary health care center in Spain.
321 consecutive male patients with chronic obstructive pulmonary disease.
Functional respiratory impairment, FEV1, respiratory symptoms, and health-related quality of life. Respiratory symptoms and health-related quality of life were measured by using the Spanish version of the St. George's Respiratory Questionnaire and the Nottingham Health Profile.
Patient scores on the St. George's Respiratory Questionnaire were moderately to strongly associated with disease staging (r = 0.27 to 0.51). Compared with reference values, values for health-related quality of life for patients with stage I disease were substantially higher on the St. George's Respiratory Questionnaire (6 and 34; P < 0.001) and values for impairment were significantly greater in stage I patients with comorbid conditions (19 and 36; P = 0.001). At least one concomitant chronic condition was found in 84% of study patients. Comorbid conditions only partly influenced the observed pattern of deterioration of health-related quality of life with worsening stages of disease.
Staging criteria for chronic obstructive pulmonary disease based on percentage of predicted FEV1 separated groups of patients with varying degrees of impairment in health-related quality of life. Contrary to expectations, even patients with mild disease showed substantially compromised health-related quality of life. Comorbid conditions influenced the relation between chronic obstructive pulmonary disease and health-related quality of life.
Ferrer M, Alonso J, Morera J, Marrades RM, Khalaf A, Aguar MC, et al. Chronic Obstructive Pulmonary Disease Stage and Health-Related Quality of Life. Ann Intern Med. 1997;127:1072–1079. doi: 10.7326/0003-4819-127-12-199712150-00003
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Published: Ann Intern Med. 1997;127(12):1072-1079.
Chronic Obstructive Airway Disease, Pulmonary/Critical Care.
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Print ISSN: 0003-4819 | Online ISSN: 1539-3704
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