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Letters |15 December 1997

Meningitis and Skin Reaction after Intravenous Immune Globulin Therapy

Benoit Catteau; Emmanuel Delaporte; Frederic Piette

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Author, Article, and Disclosure Information
  • University Hospital Center Lille; 59037 Lille Cedex, France
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TO THE EDITOR:
We read with interest the article by Dalakas on IVIg therapy in neurologic diseases, especially the section on skin reactions [1]. We observed a cutaneous reaction to IVIg, clinically typical of pompholyx, in two male patients. These patients were 34 and 61 years of age and were treated for the Guillain-Barre syndrome and chronic inflammatory demyelinating polyneuropathy, respectively, with IVIg (0.4 g/kg of body weight over 5 days).
One patient developed nonpruritic palmoplantar vesicular lesions 5 days after the start of therapy. The other had slightly pruritic erythema and vesicles on the lateral aspects of the fingers and palms 2 days after the end of the first course of IVIg. The eruption recurred during the eight following courses of IVIg within 48 hours but became more and more discrete. Neither patient had hyperhydrosis, flushing, or systemic symptoms during the infusions. The eruption subsided within a few days with desquamation. The results of patch tests and prick tests with IVIg were negative.
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Catteau B, Delaporte E, Piette F. Meningitis and Skin Reaction after Intravenous Immune Globulin Therapy. Ann Intern Med. ;127:1130. doi: 10.7326/0003-4819-127-12-199712150-00021

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Published: Ann Intern Med. 1997;127(12):1130.

DOI: 10.7326/0003-4819-127-12-199712150-00021

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