Skip Navigation
Menu
Letters |1 January 1998

Zafirlukast in Asthma

Peter K. Honig, MD; Raymond Anthracite, MD; John K. Jenkins, MD

Article, Author, and Disclosure Information
Author, Article, and Disclosure Information
  • U.S. Food and Drug Administration; Rockville, MD 20857
×
FULL TEXT
TO THE EDITOR:
Suissa and colleagues' article [1] illustrates potential limitations of peer review in evaluating manuscripts submitted for publication. It also reinforces the importance of a priori designation of the primary end points and statistical methods to be used in the conduct and analysis of randomized, controlled clinical trials.
Zafirlukast was approved by the U.S. Food and Drug Administration (FDA) on 26 September 1996 for prophylaxis and long-term treatment of asthma [2]. This approval was based, in part, on the results of the large, prospective, placebo-controlled trial (study 0029) [3] that is referenced in Suissa and colleagues' article and within which the authors' investigation was conducted as a nested study. Study 0029 was designed with explicit predefined primary and secondary end points and was analyzed with prespecified statistical rules and procedures.
FULL TEXT
PDF
Not Available
Citations
Citation

Honig PK, Anthracite R, Jenkins JK. Zafirlukast in Asthma. Ann Intern Med. ;128:70. doi: 10.7326/0003-4819-128-1-199801010-00013

Download citation file:

© 2019

×
Permissions

Published: Ann Intern Med. 1998;128(1):70.

DOI: 10.7326/0003-4819-128-1-199801010-00013

0 Citations
CONTINUE WITH LIMITED ACCESS
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
acp link acp
silverchair link silverchair

Copyright © 2019 American College of Physicians. All Rights Reserved.

Print ISSN: 0003-4819 | Online ISSN: 1539-3704

Privacy Policy

|

Conditions of Use

This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy. | Accept
×

You need a subscription to this content to use this feature.

×
PDF Downloads Require Access to the Full Article.
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×
Access to this Free Content Requires Users to be Registered and Logged In. Please Choose One of the Following Options
Annals of Internal Medicine
To receive access to the full text of freely available articles, alerts, and more. You will be directed to acponline.org to complete your registration.
×