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Letters |1 January 1998

Hypertriglyceridemia and Atherosclerosis

Andrew L. Avins, MD, MPH

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Author, Article, and Disclosure Information
  • Veterans Affairs Medical Center, San Francisco; University of California, San Francisco, School of Medicine; San Francisco, CA 94121
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TO THE EDITOR:
Dr. Ginsberg's recommendations for treatment of hypertriglyceridemia [1] are not supported by currently available evidence. First, Dr. Ginsberg offers potential biochemical rationales for how hypertriglyceridemia could cause atherosclerosis. Such explanations might be true but are an insufficient basis for establishing clinical policy. Second, he correctly notes that the observational data are inconsistent; indeed, most data do not support an independent role for hypertriglyceridemia in this process [2]. Third, he cites the Helsinki Heart Study as the primary clinical trial evidence for lowering triglyceride levels to reduce risk for coronary heart disease. However, analyses from this study...
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Avins AL. Hypertriglyceridemia and Atherosclerosis. Ann Intern Med. 1998;128:74. doi: https://doi.org/10.7326/0003-4819-128-1-199801010-00023

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Published: Ann Intern Med. 1998;128(1):74.

DOI: 10.7326/0003-4819-128-1-199801010-00023

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